Synthesis of Carbapenam Skeletons Using a Ruthenium-Catalyzed Cyclization Miwako Mori Yuji Kozawa Mayumi Nishida Makiko Kanamaru Kiyoko Onozuka Masanori Takimoto 10.1021/ol006510f.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Carbapenam_Skeletons_Using_a_Ruthenium-Catalyzed_Cyclization/3737253 Carbapenam is a very important skeleton of β-lactam antibiotics, and it has a highly strained structure. When enynes <b>9</b> were treated with RuH<sub>2</sub>CO(PPh<sub>3</sub>)<sub>3</sub> (10 mol %) in toluene upon heating, carbapenams<b> 10</b> were obtained in good yields. 2000-09-13 00:00:00 RuH antibiotic skeleton Cyclization yield Carbapenam Skeletons enynes 9 toluene Synthesi CO carbapenams 10 mol lactam heating