Synthesis of Carbapenam Skeletons
Using a Ruthenium-Catalyzed
Cyclization
Miwako Mori
Yuji Kozawa
Mayumi Nishida
Makiko Kanamaru
Kiyoko Onozuka
Masanori Takimoto
10.1021/ol006510f.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Carbapenam_Skeletons_Using_a_Ruthenium-Catalyzed_Cyclization/3737253
Carbapenam is a very important skeleton of β-lactam antibiotics, and it has a highly strained structure. When enynes <b>9</b> were treated with
RuH<sub>2</sub>CO(PPh<sub>3</sub>)<sub>3</sub> (10 mol %) in toluene upon heating, carbapenams<b> 10</b> were obtained in good yields.
2000-09-13 00:00:00
RuH
antibiotic
skeleton
Cyclization
yield
Carbapenam Skeletons
enynes 9
toluene
Synthesi
CO
carbapenams 10
mol
lactam
heating