Ward, Dale E. Gai, Yuanzhu Qiao, Qi A General Approach to Cyathin Diterpenes. Total Synthesis of Allocyathin B<sub>3</sub> The synthesis of allocyathin B<sub>3</sub> from an advanced intermediate possessing the ring system and relative stereochemistry but lacking the isopropyl and hydroxymethyl groups is reported. The isopropyl group was introduced by radical cyclization of a methyl propargyl acetal of an α-bromo ketone, and the hydroxymethyl group was generated by Pd-catalyzed carbonylation of a vinyl triflate. The route provides functionalized intermediates that could allow access to more complex members of the cyathin family of diterpenes. isopropyl group;Allocyathin B 3;vinyl triflate;ring system;Cyathin Diterpenes;hydroxymethyl groups;functionalized intermediates;allocyathin B 3;Total Synthesis;methyl propargyl acetal;hydroxymethyl group;General Approach;cyathin family 2000-06-17
    https://acs.figshare.com/articles/journal_contribution/A_General_Approach_to_Cyathin_Diterpenes_Total_Synthesis_of_Allocyathin_B_sub_3_sub_/3736446
10.1021/ol006026c.s001