10.1021/ol006026c.s001 Dale E. Ward Dale E. Ward Yuanzhu Gai Yuanzhu Gai Qi Qiao Qi Qiao A General Approach to Cyathin Diterpenes. Total Synthesis of Allocyathin B<sub>3</sub> American Chemical Society 2000 isopropyl group Allocyathin B 3 vinyl triflate ring system Cyathin Diterpenes hydroxymethyl groups functionalized intermediates allocyathin B 3 Total Synthesis methyl propargyl acetal hydroxymethyl group General Approach cyathin family 2000-06-17 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/A_General_Approach_to_Cyathin_Diterpenes_Total_Synthesis_of_Allocyathin_B_sub_3_sub_/3736446 The synthesis of allocyathin B<sub>3</sub> from an advanced intermediate possessing the ring system and relative stereochemistry but lacking the isopropyl and hydroxymethyl groups is reported. The isopropyl group was introduced by radical cyclization of a methyl propargyl acetal of an α-bromo ketone, and the hydroxymethyl group was generated by Pd-catalyzed carbonylation of a vinyl triflate. The route provides functionalized intermediates that could allow access to more complex members of the cyathin family of diterpenes.