10.1021/ol005831o.s001
Cindy Lou Chepanoske
Cindy
Lou Chepanoske
Charles R. Langelier
Charles R.
Langelier
Nikolas H. Chmiel
Nikolas H.
Chmiel
Sheila S. David
Sheila S.
David
Recognition of the Nonpolar Base
4-Methylindole in DNA by the DNA
Repair Adenine Glycosylase MutY
American Chemical Society
2000
DNA Repair Adenine Glycosylase MutY
MutY exhibit
DNA repair adenine glycosylase MutY
substrate recognition process
OG
2000-04-14 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Recognition_of_the_Nonpolar_Base_4-Methylindole_in_DNA_by_the_DNA_Repair_Adenine_Glycosylase_MutY/3736077
The DNA repair adenine glycosylase MutY efficiently recognizes 7-deaza-2‘-deoxyadenosine (Z) and its nonpolar isostere 4-methylindole
β-deoxynucleoside (M) opposite 7,8-dihydro-8-oxo-2‘-deoxyguanosine (OG) and G in DNA. Both wild-type and truncated MutY exhibit a 10- to
20-fold higher affinity for a duplex containing OG:M than OG:Z. More efficient recognition of M over Z by MutY may be to due the lack of
hydrogen bonding with the OG that facilitates nucleotide flipping during the substrate recognition process.