10.1021/ol005831o.s001 Cindy Lou Chepanoske Cindy Lou Chepanoske Charles R. Langelier Charles R. Langelier Nikolas H. Chmiel Nikolas H. Chmiel Sheila S. David Sheila S. David Recognition of the Nonpolar Base 4-Methylindole in DNA by the DNA Repair Adenine Glycosylase MutY American Chemical Society 2000 DNA Repair Adenine Glycosylase MutY MutY exhibit DNA repair adenine glycosylase MutY substrate recognition process OG 2000-04-14 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Recognition_of_the_Nonpolar_Base_4-Methylindole_in_DNA_by_the_DNA_Repair_Adenine_Glycosylase_MutY/3736077 The DNA repair adenine glycosylase MutY efficiently recognizes 7-deaza-2‘-deoxyadenosine (Z) and its nonpolar isostere 4-methylindole β-deoxynucleoside (M) opposite 7,8-dihydro-8-oxo-2‘-deoxyguanosine (OG) and G in DNA. Both wild-type and truncated MutY exhibit a 10- to 20-fold higher affinity for a duplex containing OG:M than OG:Z. More efficient recognition of M over Z by MutY may be to due the lack of hydrogen bonding with the OG that facilitates nucleotide flipping during the substrate recognition process.