Wang, Fan Manku, Sukhdev Hall, Dennis G. Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues Polyamine toxins HO-416b (<b>1</b>) and PhTX-433 (<b>2</b>) isolated from the venom of insects are important lead compounds in neuropharmacology. Their total synthesis has been achieved on a trityl derivatized resin in good yield and purity using a mild borane reduction protocol to access the polyamine chains from polyamide precursors. The synthesis of PhTX isomer <b>3 </b>demonstrates the potential of this strategy for the generation of branched analogues. polyamine chains;Efficient Polyamide Reduction Strategy;Solid Phase Syntheses;synthesis;trityl derivatized resin;polyamide precursors;Facilitates Access;borane reduction protocol;Polyamine;PhTX isomer 3;HO 2000-05-05
    https://acs.figshare.com/articles/journal_contribution/Solid_Phase_Syntheses_of_Polyamine_Toxins_HO-416b_and_PhTX-433_Use_of_an_Efficient_Polyamide_Reduction_Strategy_That_Facilitates_Access_to_Branched_Analogues/3736074
10.1021/ol005817b.s007