10.1021/ol005817b.s011 Fan Wang Fan Wang Sukhdev Manku Sukhdev Manku Dennis G. Hall Dennis G. Hall Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues American Chemical Society 2000 polyamine chains Efficient Polyamide Reduction Strategy Solid Phase Syntheses synthesis trityl derivatized resin polyamide precursors Facilitates Access borane reduction protocol Polyamine PhTX isomer 3 HO 2000-05-05 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Solid_Phase_Syntheses_of_Polyamine_Toxins_HO-416b_and_PhTX-433_Use_of_an_Efficient_Polyamide_Reduction_Strategy_That_Facilitates_Access_to_Branched_Analogues/3736062 Polyamine toxins HO-416b (<b>1</b>) and PhTX-433 (<b>2</b>) isolated from the venom of insects are important lead compounds in neuropharmacology. Their total synthesis has been achieved on a trityl derivatized resin in good yield and purity using a mild borane reduction protocol to access the polyamine chains from polyamide precursors. The synthesis of PhTX isomer <b>3 </b>demonstrates the potential of this strategy for the generation of branched analogues.