10.1021/ol005817b.s011
Fan Wang
Fan
Wang
Sukhdev Manku
Sukhdev
Manku
Dennis G. Hall
Dennis G.
Hall
Solid Phase Syntheses of Polyamine
Toxins HO-416b and PhTX-433. Use of
an Efficient Polyamide Reduction
Strategy That Facilitates Access to
Branched Analogues
American Chemical Society
2000
polyamine chains
Efficient Polyamide Reduction Strategy
Solid Phase Syntheses
synthesis
trityl derivatized resin
polyamide precursors
Facilitates Access
borane reduction protocol
Polyamine
PhTX isomer 3
HO
2000-05-05 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Solid_Phase_Syntheses_of_Polyamine_Toxins_HO-416b_and_PhTX-433_Use_of_an_Efficient_Polyamide_Reduction_Strategy_That_Facilitates_Access_to_Branched_Analogues/3736062
Polyamine toxins HO-416b (<b>1</b>) and PhTX-433 (<b>2</b>) isolated from the venom of insects are important lead compounds in neuropharmacology.
Their total synthesis has been achieved on a trityl derivatized resin in good yield and purity using a mild borane reduction protocol to access
the polyamine chains from polyamide precursors. The synthesis of PhTX isomer <b>3 </b>demonstrates the potential of this strategy for the generation
of branched analogues.