Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-Mediated Vinylic Substitution ShenRuichao PorcoJohn A. 2000 A new approach to the assembly of enamides is described using copper(I) carboxylate-catalyzed substitution of vinyl iodides and amides. Modified reaction conditions have been developed to synthesize the <i>O</i>-methyloxime enamide side chains related to the natural products lobatamides A−F, oximidine I and II, and CJ-12 950.