10.1021/jo9800210.s001 Young-Dae Gong Young-Dae Gong Samir Najdi Samir Najdi Marilyn M. Olmstead Marilyn M. Olmstead Mark J. Kurth Mark J. Kurth Solid-Phase Synthesis:  Intramolecular Azomethine Ylide Cycloaddition (→Proline) and Carbanilide Cyclization (→Hydantoin) Reactions American Chemical Society 1998 carbanilide cyclization chemistries Cyclization Experiment intramolecular pyrrolo Proline cycloaddition diastereoselective route Ylide Hydantoin tetrasubstituted glycinate Azomethine Synthesi spacer moiety ylide dipolar stereoselectivity cyclative release step phase azomethine resin Cycloaddition Intramolecular Carbanilide imidazole 1998-04-09 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Solid-Phase_Synthesis_Intramolecular_Azomethine_Ylide_Cycloaddition_Proline_and_Carbanilide_Cyclization_Hydantoin_Reactions/3709503 An efficient, diastereoselective route to 2,5,6,7-tetrasubstituted-1<i>H</i>-pyrrolo[1,2-<i>c</i>]imidazoles has been developed using solid-phase intramolecular azomethine ylide cycloaddition and carbanilide cyclization chemistries. To successfully execute this eight-step protocol in the solid phase, it was necessary to insert a spacer moiety between the resin and glycinate functional group. Experiments addressing the stereoselectivity of the 1,3-dipolar cycloaddition step as well as the cyclative release step are also presented.