Kottamides A−D: Novel Bioactive
Imidazolone-Containing Alkaloids from the
New Zealand Ascidian <i>Pycnoclavella </i><i>k</i><i>ottae</i>
David R. Appleton
Michael J. Page
Gretchen Lambert
Michael V. Berridge
Brent R. Copp
10.1021/jo0201427.s001
https://acs.figshare.com/articles/journal_contribution/Kottamides_A_D_Novel_Bioactive_Imidazolone-Containing_Alkaloids_from_the_New_Zealand_Ascidian_i_Pycnoclavella_i_i_k_i_i_ottae_i_/3693312
Kottamides A−D (<b>1</b>−<b>4</b>), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from
the New Zealand endemic ascidian <i>Pycnoclavella kottae</i> and
structurally characterized using <sup>15</sup>N natural abundance 2-D
NMR in addition to standard spectroscopic methods. The
kottamides exhibited anti-inflammatory and anti-metabolic
activity as well as cytotoxicity toward tumor cell lines.
2002-06-18 00:00:00
15 N
ascidian Pycnoclavella kottae
alkaloids
cytotoxicity
tumor cell lines
Bioactive
trisubstituted
NMR
New Zealand
abundance
kottamide
spectroscopic methods
Alkaloid
New Zealand Ascidian Pycnoclavella k ottae Kottamides