Kottamides A−D:  Novel Bioactive Imidazolone-Containing Alkaloids from the New Zealand Ascidian <i>Pycnoclavella </i><i>k</i><i>ottae</i> David R. Appleton Michael J. Page Gretchen Lambert Michael V. Berridge Brent R. Copp 10.1021/jo0201427.s001 https://acs.figshare.com/articles/journal_contribution/Kottamides_A_D_Novel_Bioactive_Imidazolone-Containing_Alkaloids_from_the_New_Zealand_Ascidian_i_Pycnoclavella_i_i_k_i_i_ottae_i_/3693312 Kottamides A−D (<b>1</b>−<b>4</b>), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from the New Zealand endemic ascidian <i>Pycnoclavella kottae</i> and structurally characterized using <sup>15</sup>N natural abundance 2-D NMR in addition to standard spectroscopic methods. The kottamides exhibited anti-inflammatory and anti-metabolic activity as well as cytotoxicity toward tumor cell lines. 2002-06-18 00:00:00 15 N ascidian Pycnoclavella kottae alkaloids cytotoxicity tumor cell lines Bioactive trisubstituted NMR New Zealand abundance kottamide spectroscopic methods Alkaloid New Zealand Ascidian Pycnoclavella k ottae Kottamides