%0 Journal Article %A Liu, Jian %A Castro, René %A Abboud, Khalil A. %A Kaifer, Angel E. %D 2000 %T Novel Ferrocenyl Polyene Derivatives and Their Binding to Unmodified Cyclodextrins %U https://acs.figshare.com/articles/journal_contribution/Novel_Ferrocenyl_Polyene_Derivatives_and_Their_Binding_to_Unmodified_Cyclodextrins/3685776 %R 10.1021/jo000573u.s001 %2 https://acs.figshare.com/ndownloader/files/5776134 %K ferrocene derivatives %K triene chain %K Novel Ferrocenyl Polyene Derivatives %K ferrocene residue %K cyclopentadienyl rings %K Unmodified Cyclodextrins %K electrochemical properties %K site selectivity %K complexation processes %K absorption measurements binding constants %K Electrochemical measurements %K ferrocene moiety %X Two new ferrocene derivatives, 7-ferrocenyl-2,4,6-heptatrienal (1) and 7-ferrocenyl-2,4,6-heptatrienol (2), were synthesized and characterized. These two compounds possess a rigid triene chain conjugated to one of the cyclopentadienyl rings of the ferrocene residue, and as a result, they exhibit very stiff structures. The electronic absorption and electrochemical properties of these compounds were utilized to investigate their host−guest binding interactions with the receptors α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) in aqueous solution. From electronic absorption measurements binding constants in the range 790−12900 M-1 were obtained; β-CD formed more stable complexes than α-CD with both guests. Electrochemical measurements suggest some degree of site selectivity in the complexation processes, with β-CD binding preferentially to the ferrocene moiety while α-CD interacts with the unsaturated chain. %I ACS Publications