Novel Ferrocenyl Polyene Derivatives and Their Binding to Unmodified Cyclodextrins Jian Liu René Castro Khalil A. Abboud Angel E. Kaifer 10.1021/jo000573u.s001 https://acs.figshare.com/articles/journal_contribution/Novel_Ferrocenyl_Polyene_Derivatives_and_Their_Binding_to_Unmodified_Cyclodextrins/3685776 Two new ferrocene derivatives, 7-ferrocenyl-2,4,6-heptatrienal (<b>1</b>) and 7-ferrocenyl-2,4,6-heptatrienol (<b>2</b>), were synthesized and characterized. These two compounds possess a rigid triene chain conjugated to one of the cyclopentadienyl rings of the ferrocene residue, and as a result, they exhibit very stiff structures. The electronic absorption and electrochemical properties of these compounds were utilized to investigate their host−guest binding interactions with the receptors α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) in aqueous solution. From electronic absorption measurements binding constants in the range 790−12900 M<sup>-1</sup> were obtained; β-CD formed more stable complexes than α-CD with both guests. Electrochemical measurements suggest some degree of site selectivity in the complexation processes, with β-CD binding preferentially to the ferrocene moiety while α-CD interacts with the unsaturated chain. 2000-09-14 00:00:00 ferrocene derivatives triene chain Novel Ferrocenyl Polyene Derivatives ferrocene residue cyclopentadienyl rings Unmodified Cyclodextrins electrochemical properties site selectivity complexation processes absorption measurements binding constants Electrochemical measurements ferrocene moiety