Lipophilic 4-Isoxazolyl-1,4-dihydropyridines:  Synthesis and Structure−Activity
Relationships
Nicholas R. Natale
Mark E. Rogers
Richard Staples
David J. Triggle
Aleta Rutledge
10.1021/jm980439q.s001
https://acs.figshare.com/articles/journal_contribution/Lipophilic_4-Isoxazolyl-1_4-dihydropyridines_Synthesis_and_Structure_Activity_Relationships/3683973
A series of 4-isoxazolyl-1,4-dihydropyridines bearing lipophilic side chains at the C-5 position
of the isoxazole ring have been prepared. The calcium channel antagonistic activity of these
compounds has been evaluated. A hypothetical model for binding of these compounds in the
calcium channel is proposed, and the validity of this model is evaluated based on the SAR of
this series of calcium binding, especially for the two most active derivatives, <b>1a</b>,<b>g</b>. The solid-state structure for the most active compound, <b>1a</b>, has also been determined, and its important
features are reported.
1999-07-16 00:00:00
calcium channel
series
binding
SAR
lipophilic side chains
compound
model