Tung, Jay S. Davis, David L. P. Anderson, John Walker, Don E. Mamo, Shumeye Jewett, Nancy Hom, Roy K. Sinha, Sukanto Thorsett, Eugene D. John, Varghese Design of Substrate-Based Inhibitors of Human β-Secretase By use of the effectively cleaved <i>β</i>-secretase (BACE) substrate (<b>1</b>), incorporation of a statine in P<sub>1</sub> resulted in a weak inhibitor <b>13 </b>of the enzyme. Further substitution of P<sub>1</sub>‘-Asp by P<sub>1</sub>‘-Val in <b>13</b> results in a potent inhibitor <b>22</b> of BACE. Removal of the P<sub>10</sub>−P<sub>5</sub> residues on the N-terminal part of inhibitor <b>22</b> resulted in no loss of potency (<b>23</b>). C-terminal truncations of inhibitor <b>22</b> generally led to significant loss of potency. BACE;inhibitor 22;potency 2001-12-20
    https://acs.figshare.com/articles/journal_contribution/Design_of_Substrate-Based_Inhibitors_of_Human_-Secretase/3680889
10.1021/jm0155695.s001