Inhibitors of Human Histone
Deacetylase: Synthesis and Enzyme and
Cellular Activity of Straight Chain
Hydroxamates
Stacy W. Remiszewski
Lidia C. Sambucetti
Peter Atadja
Kenneth W. Bair
Wendy D. Cornell
Michael A. Green
Kobporn Lulu Howell
Manfred Jung
Paul Kwon
Nancy Trogani
Heather Walker
10.1021/jm015568c.s002
https://acs.figshare.com/articles/journal_contribution/Inhibitors_of_Human_Histone_Deacetylase_Synthesis_and_Enzyme_and_Cellular_Activity_of_Straight_Chain_Hydroxamates/3680886
Inhibitors of histone deacetylase (HDAC) have been
shown to induce terminal differentiation of human tumor cell
lines and to have antitumor effects in vivo. We have prepared
analogues of suberoylanilide hydroxamic acid (SAHA) and
trichostatin A and have evaluated them in a human HDAC
enzyme inhibition assay, a p21<sup>waf1</sup> (p21) promoter assay, and
in monolayer growth inhibition assays. One compound, 4-(dimethylamino)-<i>N</i>-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, was
found to affect the growth of a panel of eight human tumor
cell lines differentially.
2002-01-17 00:00:00
histone deacetylase
Straight Chain Hydroxamates Inhibitors
monolayer growth inhibition assays
p 21 waf 1
HDAC enzyme inhibition assay
tumor cell lines
terminal differentiation
SAHA
Cellular Activity
tumor cell lines differentially
suberoylanilide hydroxamic acid
antitumor effects