%0 Journal Article
%A Tanikawa, Tetsuya
%A Asaka, Toshifumi
%A Kashimura, Masato
%A Misawa, Yoko
%A Suzuki, Keiko
%A Sato, Masakazu
%A Kameo, Kazuya
%A Morimoto, Shigeo
%A Nishida, Atsushi
%D 2001
%T Synthesis and Antibacterial Activity of
Acylides (3-O-Acyl-erythromycin
Derivatives): A Novel Class of Macrolide
Antibiotics
%U https://acs.figshare.com/articles/journal_contribution/Synthesis_and_Antibacterial_Activity_of_Acylides_3-_i_O_i_-Acyl-erythromycin_Derivatives_A_Novel_Class_of_Macrolide_Antibiotics/3680880
%R 10.1021/jm015566s.s001
%2 https://acs.figshare.com/ndownloader/files/5770662
%K pneumoniae
%K Novel Class
%K Staphylococcus aureus
%K novel class
%K Derivative
%K Acylide
%K Macrolide Antibiotics Introduction
%K acyl group
%K derivative
%K pathogen
%K Synthesi
%K Antibacterial Activity
%K TEA 0777
%K inducibly
%K macrolide antibiotics
%K MLS
%K acylide
%K nitrophenylacetyl
%K Streptococcus
%K erythromycin
%X Introduction of an acyl group to the 3-O-position
of erythromycin A derivatives instead of l-cladinose led to a
novel class of macrolide antibiotics that we named “acylides”.
The 3-O-nitrophenylacetyl derivative TEA0777 showed significantly potent activity against not only erythromycin-susceptible Gram-positive pathogens but also inducibly macrolides-lincosamides-streptogramin B (MLSB)-resistant Staphylococcus aureus and efflux-resistant Streptococcus pneumoniae.
These results indicated that acylides have potential as next-generation macrolide antibiotics.
%I ACS Publications