%0 Journal Article %A Tanikawa, Tetsuya %A Asaka, Toshifumi %A Kashimura, Masato %A Misawa, Yoko %A Suzuki, Keiko %A Sato, Masakazu %A Kameo, Kazuya %A Morimoto, Shigeo %A Nishida, Atsushi %D 2001 %T Synthesis and Antibacterial Activity of Acylides (3-O-Acyl-erythromycin Derivatives):  A Novel Class of Macrolide Antibiotics %U https://acs.figshare.com/articles/journal_contribution/Synthesis_and_Antibacterial_Activity_of_Acylides_3-_i_O_i_-Acyl-erythromycin_Derivatives_A_Novel_Class_of_Macrolide_Antibiotics/3680880 %R 10.1021/jm015566s.s001 %2 https://acs.figshare.com/ndownloader/files/5770662 %K pneumoniae %K Novel Class %K Staphylococcus aureus %K novel class %K Derivative %K Acylide %K Macrolide Antibiotics Introduction %K acyl group %K derivative %K pathogen %K Synthesi %K Antibacterial Activity %K TEA 0777 %K inducibly %K macrolide antibiotics %K MLS %K acylide %K nitrophenylacetyl %K Streptococcus %K erythromycin %X Introduction of an acyl group to the 3-O-position of erythromycin A derivatives instead of l-cladinose led to a novel class of macrolide antibiotics that we named “acylides”. The 3-O-nitrophenylacetyl derivative TEA0777 showed significantly potent activity against not only erythromycin-susceptible Gram-positive pathogens but also inducibly macrolides-lincosamides-streptogramin B (MLSB)-resistant Staphylococcus aureus and efflux-resistant Streptococcus pneumoniae. These results indicated that acylides have potential as next-generation macrolide antibiotics. %I ACS Publications