10.1021/jm015566s.s001
Tetsuya Tanikawa
Tetsuya
Tanikawa
Toshifumi Asaka
Toshifumi
Asaka
Masato Kashimura
Masato
Kashimura
Yoko Misawa
Yoko
Misawa
Keiko Suzuki
Keiko
Suzuki
Masakazu Sato
Masakazu
Sato
Kazuya Kameo
Kazuya
Kameo
Shigeo Morimoto
Shigeo
Morimoto
Atsushi Nishida
Atsushi
Nishida
Synthesis and Antibacterial Activity of
Acylides (3-<i>O</i>-Acyl-erythromycin
Derivatives): A Novel Class of Macrolide
Antibiotics
American Chemical Society
2001
pneumoniae
Novel Class
Staphylococcus aureus
novel class
Derivative
Acylide
Macrolide Antibiotics Introduction
acyl group
derivative
pathogen
Synthesi
Antibacterial Activity
TEA 0777
inducibly
macrolide antibiotics
MLS
acylide
nitrophenylacetyl
Streptococcus
erythromycin
2001-10-27 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Synthesis_and_Antibacterial_Activity_of_Acylides_3-_i_O_i_-Acyl-erythromycin_Derivatives_A_Novel_Class_of_Macrolide_Antibiotics/3680880
Introduction of an acyl group to the 3-<i>O</i>-position
of erythromycin A derivatives instead of l-cladinose led to a
novel class of macrolide antibiotics that we named “acylides”.
The 3-<i>O</i>-nitrophenylacetyl derivative TEA0777 showed significantly potent activity against not only erythromycin-susceptible Gram-positive pathogens but also inducibly macrolides-lincosamides-streptogramin B (MLS<sub>B</sub>)-resistant <i>Staphylococcus aureus</i> and efflux-resistant <i>Streptococcus pneumoniae</i>.
These results indicated that acylides have potential as next-generation macrolide antibiotics.