10.1021/jm015566s.s001 Tetsuya Tanikawa Tetsuya Tanikawa Toshifumi Asaka Toshifumi Asaka Masato Kashimura Masato Kashimura Yoko Misawa Yoko Misawa Keiko Suzuki Keiko Suzuki Masakazu Sato Masakazu Sato Kazuya Kameo Kazuya Kameo Shigeo Morimoto Shigeo Morimoto Atsushi Nishida Atsushi Nishida Synthesis and Antibacterial Activity of Acylides (3-<i>O</i>-Acyl-erythromycin Derivatives):  A Novel Class of Macrolide Antibiotics American Chemical Society 2001 pneumoniae Novel Class Staphylococcus aureus novel class Derivative Acylide Macrolide Antibiotics Introduction acyl group derivative pathogen Synthesi Antibacterial Activity TEA 0777 inducibly macrolide antibiotics MLS acylide nitrophenylacetyl Streptococcus erythromycin 2001-10-27 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Synthesis_and_Antibacterial_Activity_of_Acylides_3-_i_O_i_-Acyl-erythromycin_Derivatives_A_Novel_Class_of_Macrolide_Antibiotics/3680880 Introduction of an acyl group to the 3-<i>O</i>-position of erythromycin A derivatives instead of l-cladinose led to a novel class of macrolide antibiotics that we named “acylides”. The 3-<i>O</i>-nitrophenylacetyl derivative TEA0777 showed significantly potent activity against not only erythromycin-susceptible Gram-positive pathogens but also inducibly macrolides-lincosamides-streptogramin B (MLS<sub>B</sub>)-resistant <i>Staphylococcus aureus</i> and efflux-resistant <i>Streptococcus pneumoniae</i>. These results indicated that acylides have potential as next-generation macrolide antibiotics.