Lloyd, John Schmidt, Joan B. Rovnyak, George Ahmad, Saleem Atwal, Karnail S. Bisaha, Sharon N. Doweyko, Lidia M. Stein, Philip D. Traeger, Sarah C. Mathur, Arvind Conder, Mary Lee DiMarco, John Harper, Timothy W. Jenkins-West, Tonya Levesque, Paul C. Normandin, Diane E. Russell, Anita D. Serafino, Randolph P. Smith, Mark A. Lodge, Nicholas J. Design and Synthesis of 4-Substituted Benzamides as Potent, Selective, and Orally Bioavailable <i>I</i><sub>Ks</sub> Blockers Multiple delayed rectifier potassium currents, including <i>I</i><sub>Ks</sub>, are responsible for the repolarization and termination of the cardiac action potential, and blockers of these currents may be useful as antiarrhythmic agents. Modification of compound <b>5</b> produced <b>19(S)</b> that is the most potent <i>I</i><sub>Ks</sub> blocker reported to date with >5000-fold selectivity over other cardiac ion channels. Further modification produced <b>24A</b> with 23% oral bioavailability. compound 5;selectivity;Modification;ion channels;antiarrhythmic agents;Substituted;modification;Synthesi;bioavailability;rectifier potassium currents;Ks Blockers Multiple;Benzamide;repolarization;Ks blocker;Orally Bioavailable;Selective;Potent;termination 2001-10-17
    https://acs.figshare.com/articles/journal_contribution/Design_and_Synthesis_of_4-Substituted_Benzamides_as_Potent_Selective_and_Orally_Bioavailable_i_I_i_sub_Ks_sub_Blockers/3680787
10.1021/jm015505u.s002