10.1021/ja037423w.s004
Gireesh M. Mahandru
Gireesh M.
Mahandru
Andy R. L. Skauge
Andy R. L.
Skauge
Sanjoy K. Chowdhury
Sanjoy K.
Chowdhury
Kande K. D. Amarasinghe
Kande
K. D. Amarasinghe
Mary Jane Heeg
Mary Jane
Heeg
John Montgomery
John
Montgomery
Cascade Cyclizations and Couplings Involving Nickel
Enolates
American Chemical Society
2003
cascade Cyclizations
Nickel enolates
acyclic precursors
oxidative cyclization
nickel enolates
intramolecular versions
cascade cyclization processes
alkylation processes
Nickel Enolates
2003-10-08 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Cascade_Cyclizations_and_Couplings_Involving_Nickel_Enolates/3655533
A new strategy for effecting cascade cyclization processes using nickel enolates has been
developed. Nickel enolates may be cleanly generated by the oxidative cyclization of an enal and alkyne
with Ni(0), and the resulting enolate may be functionalized by a variety of alkylation processes. Partially
and fully intramolecular versions of the process allow the rapid synthesis of complex polycyclics from simple
achiral, acyclic precursors.