10.1021/ja034191s.s002
Shin Kamijo
Shin
Kamijo
Tienan Jin
Tienan
Jin
Zhibao Huo
Zhibao
Huo
Yoshinori Yamamoto
Yoshinori
Yamamoto
Synthesis of Triazoles from Nonactivated Terminal Alkynes via the
Three-Component Coupling Reaction Using a Pd(0)−Cu(I) Bimetallic Catalyst
American Chemical Society
2003
Pd
allyl carbonate
trimethylsiyl azide
unactivated terminal alkynes
ozonolysi
Triazole
Bimetallic
cycloaddition
Catalyst
synthesis
bimetallic
allyltriazoles proceeds
Nonactivated Terminal Alkynes
formation
catalyst
deallylation
allylpalladium
propenyltriazole
yield
isomerization
Synthesi
2003-06-06 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Synthesis_of_Triazoles_from_Nonactivated_Terminal_Alkynes_via_the_Three-Component_Coupling_Reaction_Using_a_Pd_0_Cu_I_Bimetallic_Catalyst/3649695
The synthesis of triazoles via the three-component coupling reaction of unactivated terminal alkynes, allyl carbonate, and trimethylsiyl azide under the Pd(0)−Cu(I) bimetallic catalyst is developed. The reaction most probably proceeds through the formation of a π-allylpalladium azide complex and a copper-acetylide followed by a successive [3 + 2] cycloaddition. The deallylation of the resulting allyltriazoles proceeds very easily by the Ru-catalyzed isomerization followed by the ozonolysis of the resulting propenyltriazoles to give the triazoles in high yields.