%0 Generic %A Niu, Guangle %A Liu, Weimin %A Zhou, Bingjiang %A Xiao, Hongyan %A Zhang, Hongyan %A Wu, Jiasheng %A Ge, Jiechao %A Wang, Pengfei %D 2016 %T Deep-Red and Near-Infrared Xanthene Dyes for Rapid Live Cell Imaging %U https://acs.figshare.com/articles/dataset/Deep-Red_and_Near-Infrared_Xanthene_Dyes_for_Rapid_Live_Cell_Imaging/3571239 %R 10.1021/acs.joc.6b00981.s002 %2 https://acs.figshare.com/ndownloader/files/5649078 %K cell imaging %K Live cell imaging data %K xanthene dyes %K imaging properties %K HeLa cells %K theory calculations %K Rapid Live Cell Imaging %K fluorescence quantum yields %X In this work, two xanthene dyes (H-hNR and TF-hNR) have been synthesized by a convenient and efficient method. These two dyes exhibited deep-red and near-infrared emissions, high fluorescence quantum yields, and good photostability. Their structure–optical properties were investigated by X-ray crystal structure analysis and density functional theory calculations. Live cell imaging data revealed that H-hNR and TF-hNR could rapidly stain both A549 and HeLa cells with low concentrations. The excellent photophysical and imaging properties render them as promising candidates for use in live cell imaging. %I ACS Publications