Zhang, Ya-Long Chen, Chen Wang, Xiao-Bing Wu, Lin Yang, Ming-Hua Luo, Jun Zhang, Can Sun, Hong-Bin Luo, Jian-Guang Kong, Ling-Yi Rhodomyrtials A and B, Two Meroterpenoids with a Triketone-Sesquiterpene-Triketone Skeleton from <i>Rhodomyrtus tomentosa</i>: Structural Elucidation and Biomimetic Synthesis Rhodomyrtials A and B (<b>1</b> and <b>2</b>), two unprecedented triketone-sesquiterpene-triketone adducts, along with five biogenetically related intermediates, rhodomentone A (<b>3</b>) and tomentodiones A–D (<b>4</b>–<b>7</b>), were isolated from the leaves of <i>Rhodomyrtus tomentosa</i>. Their structures and absolute configurations were determined by a combination of NMR spectroscopy, chemical conversion, and X-ray diffraction analysis. Compounds <b>1</b> and <b>2</b> were biomimetically synthesized via <b>5</b> and <b>4</b>, respectively, rather than <b>3</b>, revealing their key ordering of biosynthetic events and confirming their structural assignments. Compound <b>7</b> exhibited potent metastatic inhibitory activity against DLD-1 cells by suppressing the activation of matrix metalloproteinase (MMP)-2 and MMP-9. adduct;Rhodomyrtus tomentosa;tomentodione;MMP;chemical;conversion;matrix;biosynthetic;Compound;metalloproteinase;assignment;combination;DLD;activation;NMR;metastatic;intermediate;Meroterpenoid;configuration;Elucidation;Skeleton;diffraction;analysis;Biomimetic Synthesis Rhodomyrtials;biogenetically;spectroscopy;rhodomentone;Structural;biomimetically 2016-08-02
    https://acs.figshare.com/articles/dataset/Rhodomyrtials_A_and_B_Two_Meroterpenoids_with_a_Triketone-Sesquiterpene-Triketone_Skeleton_from_i_Rhodomyrtus_tomentosa_i_Structural_Elucidation_and_Biomimetic_Synthesis/3509741
10.1021/acs.orglett.6b01944.s006