Palladium-Catalyzed Regioselective Difluoroalkylation and Carbonylation of Alkynes Qiang Wang Yu-Tao He Jia-Hui Zhao Yi-Feng Qiu Lan Zheng Jing-Yuan Hu Yu-Chen Yang Xue-Yuan Liu Yong-Min Liang 10.1021/acs.orglett.6b01038.s002 https://acs.figshare.com/articles/dataset/Palladium-Catalyzed_Regioselective_Difluoroalkylation_and_Carbonylation_of_Alkynes/3384589 A novel, four-component synthetic strategy to synthesize a series of β<i>-</i>difluoroalkyl unsaturated esters/amides with high regioslectivity is described. This Pd-catalyzed difluoroalkylation and carbonylation reaction can be carried out with simple starting materials. Through this protocol, two new C–C bonds (including one C–CF<sub>2</sub> bond) and one C–O­(N) bond are constructed simultaneously in a single step. The synthetic utility of this reaction system has been certified by the applicability to a wide scope of alkynes and nucleophiles. Preliminary mechanistic studies suggest that the difluoroalkyl radical pathway is involved in this reaction. 2016-05-18 00:00:00 carbonylation reaction difluoroalkyl reaction system bond