Palladium-Catalyzed Regioselective Difluoroalkylation
and Carbonylation of Alkynes
Qiang Wang
Yu-Tao He
Jia-Hui Zhao
Yi-Feng Qiu
Lan Zheng
Jing-Yuan Hu
Yu-Chen Yang
Xue-Yuan Liu
Yong-Min Liang
10.1021/acs.orglett.6b01038.s002
https://acs.figshare.com/articles/dataset/Palladium-Catalyzed_Regioselective_Difluoroalkylation_and_Carbonylation_of_Alkynes/3384589
A novel, four-component synthetic
strategy to synthesize a series
of β<i>-</i>difluoroalkyl unsaturated esters/amides
with high regioslectivity is described. This Pd-catalyzed difluoroalkylation
and carbonylation reaction can be carried out with simple starting
materials. Through this protocol, two new C–C bonds (including
one C–CF<sub>2</sub> bond) and one C–O(N) bond are constructed
simultaneously in a single step. The synthetic utility of this reaction
system has been certified by the applicability to a wide scope of
alkynes and nucleophiles. Preliminary mechanistic studies suggest
that the difluoroalkyl radical pathway is involved in this reaction.
2016-05-18 00:00:00
carbonylation reaction
difluoroalkyl
reaction system
bond