Cu-Catalyzed
Stereoselective γ‑Alkylation
of Enones
Xiaohong Chen
Xiaoguang Liu
Justin T. Mohr
10.1021/jacs.6b02565.s001
https://acs.figshare.com/articles/journal_contribution/Cu_Catalyzed_Stereoselective_Alkylation_of_Enones/3382297
A general
regio- and stereoselective γ-C–C bond formation
is achieved using α-halocarbonyl compounds and dienol ethers
via Cu(II) catalysis. This method constitutes a novel approach to
the challenging 1,6-dioxygenation motif. A range of γ-substituted
enones, including many bearing all-carbon quaternary centers, are
available through a simple protocol under mild reaction conditions
with superb functional group compatibility. Excellent stereoinduction
is observed providing controlled access to challenging stereochemical
arrays.
2016-05-09 00:00:00
reaction conditions
motif
stereoselective
dienol ethers
halocarbonyl
novel approach
Excellent stereoinduction
Alkylation
dioxygenation
group compatibility
access
method
Enone
quaternary
catalysi
regio
formation
compound
enone
center
Stereoselective
stereochemical arrays
Cu
bond