Concise and Efficient Synthesis of
4-Fluoro-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine
Carl Thibault
Alexandre L'Heureux
Rajeev S. Bhide
Réjean Ruel
10.1021/ol036030z.s002
https://acs.figshare.com/articles/journal_contribution/Concise_and_Efficient_Synthesis_of_4_Fluoro_1_i_H_i_pyrrolo_2_3_i_b_i_pyridine/3355291
Two routes describing the preparation of 4-fluoro-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine (<b>4a</b>) from 1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine <i>N</i>-oxide (<b>1</b>) are presented.
Regioselective fluorination was achieved using either the Balz−Schiemann reaction or lithium−halogen exchange.
2003-12-25 00:00:00
Regioselective fluorination
pyrrolo
Efficient Synthesis
1 H
pyridine N