Ek, Fredrik Manner, Sophie Wistrand, Lars-Göran Frejd, Torbjörn Synthesis of Fused Tetrazole Derivatives via a Tandem Cycloaddition and <i>N</i>-Allylation Reaction and Parallel Synthesis of Fused Tetrazole Amines A method for the synthesis of novel fused tricyclic tetrazoles from allylic bromides generated by the recently discovered DiazAll reaction has been developed. This new tandem reaction comprises a cycloaddition between a nitrile and (TMS)N<sub>3</sub> followed by an intramolecular <i>N</i>-allylation. The variation of functionalities in the benzene moiety was well-tolerated, and only a moderate difference in yield and degree of purity was noticed. An <i>exo</i>-methylene group in these new compounds permitted further derivatization. Structural resemblance with substances which possess important pharmacological properties motivated the synthesis of a series of ketones and a small library of amines. allylic bromides;series;allylation;Parallel Synthesis;derivatization;TMS;purity;cycloaddition;Fused Tetrazole Derivatives;tricyclic tetrazoles;synthesis;Structural resemblance;amines;compound;methylene group;Allylation Reaction;variation;functionalitie;Tandem Cycloaddition;nitrile;DiazAll reaction;Fused Tetrazole Amines;benzene moiety;exo;method;tandem reaction;ketone;intramolecular N 2004-02-20
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Fused_Tetrazole_Derivatives_via_a_Tandem_Cycloaddition_and_i_N_i_Allylation_Reaction_and_Parallel_Synthesis_of_Fused_Tetrazole_Amines/3349336
10.1021/jo035498c.s003