Synthesis of Fused Tetrazole Derivatives via a Tandem Cycloaddition and <i>N</i>-Allylation Reaction and Parallel Synthesis of Fused Tetrazole Amines Fredrik Ek Sophie Manner Lars-Göran Wistrand Torbjörn Frejd 10.1021/jo035498c.s002 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Fused_Tetrazole_Derivatives_via_a_Tandem_Cycloaddition_and_i_N_i_Allylation_Reaction_and_Parallel_Synthesis_of_Fused_Tetrazole_Amines/3349330 A method for the synthesis of novel fused tricyclic tetrazoles from allylic bromides generated by the recently discovered DiazAll reaction has been developed. This new tandem reaction comprises a cycloaddition between a nitrile and (TMS)N<sub>3</sub> followed by an intramolecular <i>N</i>-allylation. The variation of functionalities in the benzene moiety was well-tolerated, and only a moderate difference in yield and degree of purity was noticed. An <i>exo</i>-methylene group in these new compounds permitted further derivatization. Structural resemblance with substances which possess important pharmacological properties motivated the synthesis of a series of ketones and a small library of amines. 2004-02-20 00:00:00 allylic bromides series allylation Parallel Synthesis derivatization TMS purity cycloaddition Fused Tetrazole Derivatives tricyclic tetrazoles synthesis Structural resemblance amines compound methylene group Allylation Reaction variation functionalitie Tandem Cycloaddition nitrile DiazAll reaction Fused Tetrazole Amines benzene moiety exo method tandem reaction ketone intramolecular N