Warren, J. David Miller, Justin S. Keding, Stacy J. Danishefsky, Samuel J. Toward Fully Synthetic Glycoproteins by Ultimately Convergent Routes:  A Solution to a Long-Standing Problem A method is disclosed for the convergent synthesis of multiply glycosylated peptides. The approach centers on a convergent technique for generating masked, complex glycopeptide-containing C-terminal acyl donors. Activation of the latent donor in situ and use directly in segment coupling with a second peptide bearing a complex carbohydrate produces a completely unprotected, bifunctional glycopeptide. The system demonstrates a minimum level of hydrolysis and epimerization at the C-terminal amino acid residue of the acyl donor during fully convergent segment coupling and is therefore a powerful tool for the synthesis of glycoproteins. bifunctional glycopeptide;convergent technique;acyl donor;approach centers;Synthetic Glycoproteins;convergent segment;acid residue;glycosylated peptides;convergent synthesis 2004-06-02
    https://acs.figshare.com/articles/journal_contribution/Toward_Fully_Synthetic_Glycoproteins_by_Ultimately_Convergent_Routes_A_Solution_to_a_Long_Standing_Problem/3337237
10.1021/ja0491836.s001