%0 Journal Article %A Warren, J. David %A Miller, Justin S. %A Keding, Stacy J. %A Danishefsky, Samuel J. %D 2004 %T Toward Fully Synthetic Glycoproteins by Ultimately Convergent Routes:  A Solution to a Long-Standing Problem %U https://acs.figshare.com/articles/journal_contribution/Toward_Fully_Synthetic_Glycoproteins_by_Ultimately_Convergent_Routes_A_Solution_to_a_Long_Standing_Problem/3337237 %R 10.1021/ja0491836.s001 %2 https://acs.figshare.com/ndownloader/files/5176453 %K bifunctional glycopeptide %K convergent technique %K acyl donor %K approach centers %K Synthetic Glycoproteins %K convergent segment %K acid residue %K glycosylated peptides %K convergent synthesis %X A method is disclosed for the convergent synthesis of multiply glycosylated peptides. The approach centers on a convergent technique for generating masked, complex glycopeptide-containing C-terminal acyl donors. Activation of the latent donor in situ and use directly in segment coupling with a second peptide bearing a complex carbohydrate produces a completely unprotected, bifunctional glycopeptide. The system demonstrates a minimum level of hydrolysis and epimerization at the C-terminal amino acid residue of the acyl donor during fully convergent segment coupling and is therefore a powerful tool for the synthesis of glycoproteins. %I ACS Publications