10.1021/ol0491890.s002 Ke-Gang Liu Ke-Gang Liu Shi Yan Shi Yan Yu-Lin Wu Yu-Lin Wu Zhu-Jun Yao Zhu-Jun Yao Synthesis of 4-Azido-4-deoxy-Neu5,7,8,9Ac<sub>4</sub>2en1Me. A Key Intermediate for the Synthesis of GG167 from d-Glucono-δ-lactone American Chemical Society 2004 Key Intermediate Azido imine diastereoselective allyllation 1Me acid chemoselective oxidations regioselective Relenza neuraminidase inhibitor GG 167 ester GG 167 synthesis methyl Zanamivir material acetyl acetamido Stereoselective vicinal diols Synthesi aziridine 2004-06-24 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Synthesis_of_4_Azido_4_deoxy_Neu5_7_8_9Ac_sub_4_sub_2en1Me_A_Key_Intermediate_for_the_Synthesis_of_GG167_from_d_Glucono_lactone/3334717 Stereoselective synthesis of 5-acetamido-7,8,9-tri-<i>O</i>-acetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-d-glycero-d-galacto-non-2-enonic acid methyl ester, an advanced key intermediate for the synthesis of neuraminidase inhibitor GG167 (Zanamivir, Relenza), was accomplished using d-glucono-δ-lactone as starting material. A highly diastereoselective allyllation of an imine intermediate, a regioselective azide-opening of an aziridine, and chemoselective oxidations of vicinal diols served successfully as key steps.