%0 Journal Article %A Reyes, Fernando %A Ardá, Ana %A Martín, Rocío %A Fernández, Rogelio %A Rueda, Ana %A Montalvo, David %A Gómez, Cristina %A Jiménez, Carlos %A Rodríguez, Jaime %A Sánchez-Puelles, José M %D 2004 %T New Cytotoxic Cembranes from the Sea Pen Gyrophyllum sibogae %U https://acs.figshare.com/articles/journal_contribution/New_Cytotoxic_Cembranes_from_the_Sea_Pen_i_Gyrophyllum_i_i_s_i_i_ibogae_i_/3331318 %R 10.1021/np049903m.s001 %2 https://acs.figshare.com/ndownloader/files/5170528 %K metabolite 1 %K New Cytotoxic Cembranes %K 13 tumor cell lines %K basis %K sea pen Gyrophyllum sibogae %K dihydroflabellatene %K diterpenoid %K spectroscopic analysis %K South %K panel %K cytotoxicity %K propanol %K Sea Pen Gyrophyllum %X Two new cembrane-type diterpenoids have been isolated from the 2-propanol extract of the sea pen Gyrophyllum sibogae collected in South Africa:  7,8-dihydroflabellatene A (1) and 7,8-dihydroflabellatene B (2). Their structures were determined on the basis of detailed spectroscopic analysis and by single-crystal X-ray analysis of the major metabolite 1, which showed strong in vitro cytotoxicity against a panel of 13 tumor cell lines. %I ACS Publications