%0 Journal Article
%A Reyes, Fernando
%A Ardá, Ana
%A Martín, Rocío
%A Fernández, Rogelio
%A Rueda, Ana
%A Montalvo, David
%A Gómez, Cristina
%A Jiménez, Carlos
%A Rodríguez, Jaime
%A Sánchez-Puelles, José M
%D 2004
%T New Cytotoxic Cembranes from the Sea Pen Gyrophyllum sibogae
%U https://acs.figshare.com/articles/journal_contribution/New_Cytotoxic_Cembranes_from_the_Sea_Pen_i_Gyrophyllum_i_i_s_i_i_ibogae_i_/3331318
%R 10.1021/np049903m.s001
%2 https://acs.figshare.com/ndownloader/files/5170528
%K metabolite 1
%K New Cytotoxic Cembranes
%K 13 tumor cell lines
%K basis
%K sea pen Gyrophyllum sibogae
%K dihydroflabellatene
%K diterpenoid
%K spectroscopic analysis
%K South
%K panel
%K cytotoxicity
%K propanol
%K Sea Pen Gyrophyllum
%X Two new cembrane-type diterpenoids have been isolated from the 2-propanol extract of the sea pen
Gyrophyllum sibogae collected in South Africa: 7,8-dihydroflabellatene A (1) and 7,8-dihydroflabellatene
B (2). Their structures were determined on the basis of detailed spectroscopic analysis and by single-crystal X-ray analysis of the major metabolite 1, which showed strong in vitro cytotoxicity against a
panel of 13 tumor cell lines.
%I ACS Publications