10.1021/ol048907f.s001
Jin-Heng Li
Jin-Heng
Li
Wen-Jie Liu
Wen-Jie
Liu
Dabco as an Inexpensive and Highly
Efficient Ligand for Palladium-Catalyzed
Suzuki−Miyaura Cross-Coupling
Reaction
American Chemical Society
2004
arylboronic acids
Dabco
Pd
Suzuki
2004-08-05 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Dabco_as_an_Inexpensive_and_Highly_Efficient_Ligand_for_Palladium_Catalyzed_Suzuki_Miyaura_Cross_Coupling_Reaction/3329815
An inexpensive and highly efficient Pd(OAc)<sub>2</sub>/Dabco catalytic system has been developed for the cross-coupling of aryl halides with arylboronic
acids. A combination of Pd(OAc)<sub>2</sub> and Dabco (triethylenediamine) was observed to form an excellent catalyst, which affords high TONs (turnover
numbers; TONs up to 950 000 for the reaction of PhI and <i>p</i>-chlorophenylboronic acid) for Suzuki−Miyaura cross-coupling of various aryl
iodides and bromides with arylboronic acids.