Shreder, Kevin R. Wong, Melissa S. Nomanbhoy, Tyzoon S. Leventhal, Phillip Fuller, Stacy R. Synthesis of AX7593, a Quinazoline-Derived Photoaffinity Probe for EGFR The synthesis of a photoaffinity probe for EGFR is described. O-Alkylation of 4-(<i>meta</i>-azidoanilino)-6-methoxy-7-hydroxy-quinazoline with a protected tetraethyleneglycol linker followed by the attachment of tetramethylrhodamine yielded the fluorescent probe AX7593. Photoaffinity labeling of EGFR by <b>AX7593</b> (<i>K</i><sub>b</sub> = 280 nM) was shown to have an efficiency of 34% and to be competitive with the EGFR inhibitors PP2 and AG1478. 280 nM;K b;tetraethyleneglycol linker;probe AX 7593. Photoaffinity;EGFR inhibitors PP 2;photoaffinity probe;AG;AX 7593 2004-10-14
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_AX7593_a_Quinazoline_Derived_Photoaffinity_Probe_for_EGFR/3320950
10.1021/ol048656a.s001