Synthesis of Disubstituted
Imidazo[4,5-<i>b</i>]pyridin-2-ones
Jeffrey T. Kuethe
Audrey Wong
Ian W. Davies
10.1021/jo048887v.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Disubstituted_Imidazo_4_5_i_b_i_pyridin_2_ones/3318412
Regioselective palladium-catalyzed amination of
2-chloro-3-iodopyridine followed by a subsequent palladium-catalyzed amination leads to 2,3-diaminopyridines. Treatment with triphosgene affords highly functionalized unsymmetrical imidazo[4,5-<i>b</i>]pyridin-2-ones in just three synthetic
steps. A two-step synthesis of pseudosymmetrically disubstituted imidazo[4,5-<i>b</i>]pyridin-2-ones, 1,4-disubstituted pyrido[2,3-<i>b</i>]pyrazinediones, and 1,3-disubstituted thiadiazolo[3,4-<i>b</i>]pyridin-2-ones is also described.
2004-10-29 00:00:00
disubstituted
amination
pyridin
imidazo