10.1021/ja046001z.s001 Jonathan R. Nitschke Jonathan R. Nitschke David Schultz David Schultz Gérald Bernardinelli Gérald Bernardinelli David Gérard David Gérard Selection Rules for Helicate Ligand Component Self-Assembly:  Steric, pH, Charge, and Solvent Effects American Chemical Society 2004 pH Selection Rules Solvent Effects steric bulk aliphatic amine 2004-12-22 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Selection_Rules_for_Helicate_Ligand_Component_Self_Assembly_Steric_pH_Charge_and_Solvent_Effects/3311236 The reaction between 1,10-phenanthroline-2,9-dicarboxaldehyde, copper(I), and certain primary amines was found to give quantitatively a dicopper double-helicate product (two of which were crystallographically characterized) by imine self-assembly around Cu<sup>I</sup> templates. The parameters of this reaction were investigated, and important roles were found to be played by (i) the steric bulk of the amine, (ii) the charge of the amine, (iii) the solvent used, and (iv) the pH of the solution. Water was found to allow the broadest range of structures to form, and ligand-component exchange reactions (involving the substitution of an aromatic for an aliphatic amine) were demonstrated to proceed readily in this solvent.