Oxabicyclo[3.2.1]octane Derivatives as Highly Reactive Dienophiles:  Synthesis of Bicyclo[5.<i>n</i>.0] Systems PelphreyPhillip JasinskiJerry ButcherRay J. WrightDennis L. 2005 We have developed highly versatile, homochiral oxabicyclo[3.2.1]octadiene building blocks for the synthesis of natural products. We have found that these bridged alkenes undergo exceptionally facile Diels−Alder reactions and react faster than several well studied bicyclo[2.2.1]heptene dienophiles. The reaction proceeds with high levels of stereochemical control and in very good to excellent yields, providing access to bicyclo[5.4.0]undecane and bicyclo[5.3.0]decane systems. This reactivity is attributed to strain and homoconjugation effects.