10.1021/ol047748x.s001 Xiang-Ping Hu Xiang-Ping Hu Zhuo Zheng Zhuo Zheng Practical Rh(I)-Catalyzed Asymmetric Hydrogenation of β-(Acylamino)acrylates Using a New Unsymmetrical Hybrid Ferrocenylphosphine−Phosphoramidite Ligand:  Crucial Influence of an N−H Proton in the Ligand American Chemical Society 2005 enantioselectivity unsymmetrical Ligand Acylamino presence Hybrid Hydrogenation New Rh Asymmetric hydrogenation role enantioselectivitie Ferrocenylphosphine Practical proton ligand ferrocenylphosphine Unsymmetrical alkyl Influence Proton aryl 2005-02-03 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Practical_Rh_I_Catalyzed_Asymmetric_Hydrogenation_of_Acylamino_acrylates_Using_a_New_Unsymmetrical_Hybrid_Ferrocenylphosphine_Phosphoramidite_Ligand_Crucial_Influence_of_an_N_H_Proton_in_the_Ligand/3302506 Excellent enantioselectivities and high turnovers (S/C = 5000) were achieved in the Rh(I)-catalyzed asymmetric hydrogenation of both β-aryl- and β-alkyl-β-(acylamino)acrylates with a new unsymmetrical hybrid ferrocenylphosphine−phosphoramidite ligand, and the presence of an N−H proton in the ligand was demonstrated to have a crucial role in the enantioselectivity.