10.1021/ol047748x.s001
Xiang-Ping Hu
Xiang-Ping
Hu
Zhuo Zheng
Zhuo
Zheng
Practical Rh(I)-Catalyzed Asymmetric
Hydrogenation of β-(Acylamino)acrylates
Using a New Unsymmetrical Hybrid
Ferrocenylphosphine−Phosphoramidite
Ligand: Crucial Influence of an N−H
Proton in the Ligand
American Chemical Society
2005
enantioselectivity
unsymmetrical
Ligand
Acylamino
presence
Hybrid
Hydrogenation
New
Rh
Asymmetric
hydrogenation
role
enantioselectivitie
Ferrocenylphosphine
Practical
proton
ligand
ferrocenylphosphine
Unsymmetrical
alkyl
Influence
Proton
aryl
2005-02-03 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Practical_Rh_I_Catalyzed_Asymmetric_Hydrogenation_of_Acylamino_acrylates_Using_a_New_Unsymmetrical_Hybrid_Ferrocenylphosphine_Phosphoramidite_Ligand_Crucial_Influence_of_an_N_H_Proton_in_the_Ligand/3302506
Excellent enantioselectivities and high turnovers (S/C = 5000) were achieved in the Rh(I)-catalyzed asymmetric hydrogenation of both β-aryl-
and β-alkyl-β-(acylamino)acrylates with a new unsymmetrical hybrid ferrocenylphosphine−phosphoramidite ligand, and the presence of an
N−H proton in the ligand was demonstrated to have a crucial role in the enantioselectivity.