%0 Journal Article
%A Semmelhack, Martin F.
%A Campagna, Shawn R.
%A J. Federle, Michael
%A Bassler, Bonnie L.
%D 2005
%T An Expeditious Synthesis of DPD and
Boron Binding Studies
%U https://acs.figshare.com/articles/journal_contribution/An_Expeditious_Synthesis_of_DPD_and_Boron_Binding_Studies/3300742
%R 10.1021/ol047695j.s001
%2 https://acs.figshare.com/ndownloader/files/5138476
%K marine bacteria
%K DPD
%K Vibrio harveyi
%K Boron Binding Studies
%K synthesis
%K Expeditious Synthesis
%K borate
%X A practical synthesis has been developed for DPD (4,5-dihydroxypentane-2,3-dione), an unstable small molecule that is proposed to be the
source of universal signaling agents for quorum sensing in bacteria. The synthesis allows preparation of isotopically labeled DPD and ent-DPD as well as detailed studies of spontaneous binding to borate to give the unusual borate complex 6, the signal for marine bacteria such
as Vibrio harveyi.
%I ACS Publications