%0 Journal Article %A Semmelhack, Martin F. %A Campagna, Shawn R. %A J. Federle, Michael %A Bassler, Bonnie L. %D 2005 %T An Expeditious Synthesis of DPD and Boron Binding Studies %U https://acs.figshare.com/articles/journal_contribution/An_Expeditious_Synthesis_of_DPD_and_Boron_Binding_Studies/3300742 %R 10.1021/ol047695j.s001 %2 https://acs.figshare.com/ndownloader/files/5138476 %K marine bacteria %K DPD %K Vibrio harveyi %K Boron Binding Studies %K synthesis %K Expeditious Synthesis %K borate %X A practical synthesis has been developed for DPD (4,5-dihydroxypentane-2,3-dione), an unstable small molecule that is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis allows preparation of isotopically labeled DPD and ent-DPD as well as detailed studies of spontaneous binding to borate to give the unusual borate complex 6, the signal for marine bacteria such as Vibrio harveyi. %I ACS Publications