An Expeditious Synthesis of DPD and
Boron Binding Studies
Martin F. Semmelhack
Shawn R. Campagna
Michael J. Federle
Bonnie L. Bassler
10.1021/ol047695j.s001
https://acs.figshare.com/articles/journal_contribution/An_Expeditious_Synthesis_of_DPD_and_Boron_Binding_Studies/3300742
A practical synthesis has been developed for DPD (4,5-dihydroxypentane-2,3-dione), an unstable small molecule that is proposed to be the
source of universal signaling agents for quorum sensing in bacteria. The synthesis allows preparation of isotopically labeled DPD and ent-DPD as well as detailed studies of spontaneous binding to borate to give the unusual borate complex <b>6</b>, the signal for marine bacteria such
as <i>Vibrio</i> <i>harveyi</i>.
2005-02-17 00:00:00
marine bacteria
DPD
Vibrio harveyi
Boron Binding Studies
synthesis
Expeditious Synthesis
borate