An Expeditious Synthesis of DPD and Boron Binding Studies Martin F. Semmelhack Shawn R. Campagna Michael J. Federle Bonnie L. Bassler 10.1021/ol047695j.s001 https://acs.figshare.com/articles/journal_contribution/An_Expeditious_Synthesis_of_DPD_and_Boron_Binding_Studies/3300742 A practical synthesis has been developed for DPD (4,5-dihydroxypentane-2,3-dione), an unstable small molecule that is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis allows preparation of isotopically labeled DPD and ent-DPD as well as detailed studies of spontaneous binding to borate to give the unusual borate complex <b>6</b>, the signal for marine bacteria such as <i>Vibrio</i> <i>harveyi</i>. 2005-02-17 00:00:00 marine bacteria DPD Vibrio harveyi Boron Binding Studies synthesis Expeditious Synthesis borate