10.1021/ol047695j.s001
Martin F. Semmelhack
Martin F.
Semmelhack
Shawn R. Campagna
Shawn R.
Campagna
Michael J. Federle
Michael
J. Federle
Bonnie L. Bassler
Bonnie L.
Bassler
An Expeditious Synthesis of DPD and
Boron Binding Studies
American Chemical Society
2005
marine bacteria
DPD
Vibrio harveyi
Boron Binding Studies
synthesis
Expeditious Synthesis
borate
2005-02-17 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/An_Expeditious_Synthesis_of_DPD_and_Boron_Binding_Studies/3300742
A practical synthesis has been developed for DPD (4,5-dihydroxypentane-2,3-dione), an unstable small molecule that is proposed to be the
source of universal signaling agents for quorum sensing in bacteria. The synthesis allows preparation of isotopically labeled DPD and ent-DPD as well as detailed studies of spontaneous binding to borate to give the unusual borate complex <b>6</b>, the signal for marine bacteria such
as <i>Vibrio</i> <i>harveyi</i>.