Metal Recognition of Septapeptides via
Polypod Molecular Architecture
Ersin Emre Oren
Candan Tamerler
Mehmet Sarikaya
10.1021/nl048425x.s001
https://acs.figshare.com/articles/journal_contribution/Metal_Recognition_of_Septapeptides_via_Polypod_Molecular_Architecture/3297517
The understanding of the nature of recognition of inorganic materials by proteins is one of the core elements of and has profound implications
in biological materials science and engineering. Using combinatorial display methods, a considerable number of short polypeptides have
recently been selected with affinity to engineering materials. During these selections, more than several polypeptides are identified with
binding specificity to a chosen inorganic material. Understanding the nature of surface recognition of materials by polypeptides is essential
for rational design and biomimetic engineering of these inorganic-binding polypeptides for use as linkers, catalyzers, and growth modifiers
in nanotechnology and nanobiotechnology. Although there may not be direct homology among the amino acids constituting the polypeptides,
their function may come from conserved molecular architecture. Here we study crystallographic surface recognition of platinum metal-binding
septapeptides by conformational analysis. We find that the septapeptides conform into certain molecular architectures containing multiple
protrusions (polypods) that spatially match with the crystallographic metal surfaces. While the physical recognition may originate from how
well the molecular polypods spatially match a given crystallographic surface, the degree of binding may be due to the reactive groups that
form the polypods, e.g., charged or polar groups (e.g., hydroxyl and amine). These results are highly consistent with the experimental binding
characteristics of the Pt binders with various degrees of affinities.
2005-03-09 00:00:00
g ., hydroxyl
g ., charged
direct homology among
conserved molecular architecture
amino acids constituting
given crystallographic surface
crystallographic metal surfaces
experimental binding characteristics
function may come
chosen inorganic material
biological materials science
platinum metal
binding specificity
binding septapeptides
binding may
surface recognition
various degrees
spatially match
septapeptides conform
reactive groups
rational design
pt binders
profound implications
polar groups
metal recognition
inorganic materials
highly consistent
growth modifiers
core elements
considerable number
conformational analysis
amine ).