First Enantiospecific Synthesis of the Antitumor Marine Sponge Metabolite (−)-15-Oxopuupehenol from (−)-Sclareol E. J. Alvarez-Manzaneda R. Chahboun I. Barranco Pérez E. Cabrera E. Alvarez R. Alvarez-Manzaneda 10.1021/ol047332j.s001 https://acs.figshare.com/articles/journal_contribution/First_Enantiospecific_Synthesis_of_the_Antitumor_Marine_Sponge_Metabolite_15_Oxopuupehenol_from_Sclareol/3291319 A new route toward puupehenone-related bioactive metabolites from (−)-sclareol, based on the palladium(II)-mediated diastereoselective cyclization of a drimenylphenol, is described. Utilizing this, the first enantiospecific synthesis of the antitumor and antimalarial (−)-15-oxopuupehenol, together with improved syntheses of (+)-puupehenone, (+)-puupehedione, and (+)-15-cyanopuupehenone, were accomplished. 2005-04-14 00:00:00 diastereoselective puupehenone Utilizing cyanopuupehenone drimenylphenol oxopuupehenol Antitumor enantiospecific synthesis Sclareol Oxopuupehenol Marine Metabolite antitumor antimalarial sclareol palladium First Enantiospecific Synthesis metabolite bioactive cyclization synthese puupehedione