10.1021/ol047332j.s001 E. J. Alvarez-Manzaneda E. J. Alvarez-Manzaneda R. Chahboun R. Chahboun I. Barranco Pérez I. Barranco Pérez E. Cabrera E. Cabrera E. Alvarez E. Alvarez R. Alvarez-Manzaneda R. Alvarez-Manzaneda First Enantiospecific Synthesis of the Antitumor Marine Sponge Metabolite (−)-15-Oxopuupehenol from (−)-Sclareol American Chemical Society 2005 diastereoselective puupehenone Utilizing cyanopuupehenone drimenylphenol oxopuupehenol Antitumor enantiospecific synthesis Sclareol Oxopuupehenol Marine Metabolite antitumor antimalarial sclareol palladium First Enantiospecific Synthesis metabolite bioactive cyclization synthese puupehedione 2005-04-14 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/First_Enantiospecific_Synthesis_of_the_Antitumor_Marine_Sponge_Metabolite_15_Oxopuupehenol_from_Sclareol/3291319 A new route toward puupehenone-related bioactive metabolites from (−)-sclareol, based on the palladium(II)-mediated diastereoselective cyclization of a drimenylphenol, is described. Utilizing this, the first enantiospecific synthesis of the antitumor and antimalarial (−)-15-oxopuupehenol, together with improved syntheses of (+)-puupehenone, (+)-puupehedione, and (+)-15-cyanopuupehenone, were accomplished.