10.1021/jo0500939.s002
Ana Minatti
Ana
Minatti
Karl Heinz Dötz
Karl Heinz
Dötz
Enantioselective Total Synthesis of
(−)-Curcuquinone via Regioselective
Chromium-Mediated Benzannulation
American Chemical Society
2005
Enantioselective
Regioselective
Curcuquinone
curcuhydroquinone monomethyl ether 9
Benzannulation
enantioselective
regioselective
curcuquinone
strategy
synthesis
protection
benzannulation reaction
marine
isolation
Synthesi
2005-04-29 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Enantioselective_Total_Synthesis_of_Curcuquinone_via_Regioselective_Chromium_Mediated_Benzannulation/3288778
A short and efficient, high-yielding enantioselective total
synthesis of the marine natural product (−)-curcuquinone
<b>1</b> is reported involving a regioselective [3 + 2 + 1]-benzannulation reaction as the key step. Additionally, this strategy
allows the isolation of curcuhydroquinone monomethyl ether
<b>9</b> as an intermediate of the benzannulation reaction and its
subsequent further protection toward diversified hydroquinones.