Very Fast Two-Dimensional NMR Spectroscopy for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of Seconds Paul Schanda Bernhard Brutscher 10.1021/ja051306e.s001 https://acs.figshare.com/articles/journal_contribution/Very_Fast_Two_Dimensional_NMR_Spectroscopy_for_Real_Time_Investigation_of_Dynamic_Events_in_Proteins_on_the_Time_Scale_of_Seconds/3283102 We demonstrate for different protein samples that 2D <sup>1</sup>H−<sup>15</sup>N correlation NMR spectra can be recorded in a few seconds of acquisition time using a new band-selective optimized flip-angle short-transient heteronuclear multiple quantum coherence experiment. This has enabled us to measure fast hydrogen−deuterium exchange rate constants along the backbone of a small globular protein fragment by real-time 2D NMR. 2005-06-08 00:00:00 Time Scale acquisition time globular protein fragment Dynamic Events quantum coherence experiment 2 D NMR protein samples