%0 Journal Article %A Ghalit, Nourdin %A Poot, Alex J. %A Fürstner, Alois %A T. S. Rijkers, Dirk %A M. J. Liskamp, Rob %D 2005 %T Ring-Closing Alkyne Metathesis Approach toward the Synthesis of Alkyne Mimics of Thioether A-, B-, C-, and DE-Ring Systems of the Lantibiotic Nisin Z %U https://acs.figshare.com/articles/journal_contribution/Ring_Closing_Alkyne_Metathesis_Approach_toward_the_Synthesis_of_Alkyne_Mimics_of_Thioether_A_B_C_and_DE_Ring_Systems_of_the_Lantibiotic_Nisin_Z/3278554 %R 10.1021/ol0508781.s002 %2 https://acs.figshare.com/ndownloader/files/5116300 %K acid residues %K peptide antibiotic nisin Z %K Approach %K Lantibiotic %K Alkyne Mimics %K Synthesi %K Thioether %K yield %K metathesi %K cyclic %K Metathesi %K alkyne %K mimic %K synthesis %K Nisin %X Ring-closing alkyne metathesis toward the synthesis of the alkyne-brigded A-, B-, C-, and (D)E-ring mimics of the peptide antibiotic nisin Z is described. We have successfully synthesized alkyne-bridged cyclic peptides containing 4−7 amino acid residues in yields ranging from 18 to 82%. %I ACS Publications