10.1021/ol051335u.s001
Ken Tanaka
Ken
Tanaka
Takeaki Shoji
Takeaki
Shoji
Cationic Rhodium(I)/BINAP
Complex-Catalyzed Isomerization of
Secondary Propargylic Alcohols to
α,β-Enones
American Chemical Society
2005
propargylic alcohols
Cationic
selectivity
intramolecular
migration
Rhodium
cationic
rhodium
Enone
variant
Isomerization
enone
proceed
pathway
isomerization
Secondary Propargylic Alcohols
2005-08-04 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Cationic_Rhodium_I_BINAP_Complex_Catalyzed_Isomerization_of_Secondary_Propargylic_Alcohols_to_Enones/3274633
We have developed a cationic rhodium(I)/BINAP complex-catalyzed isomerization of secondary propargylic alcohols to α,β-enones. The
asymmetric variant of this reaction, a kinetic resolution of secondary propargylic alcohols, was also developed with good selectivity. The
mechanistic study revealed that the isomerization proceeds through intramolecular 1,3- and 1,2-hydrogen migration pathways.