%0 Journal Article
%A Amat, Mercedes
%A Pérez, Maria
%A Minaglia, Annamaria T.
%A Casamitjana, Núria
%A Bosch, Joan
%D 2005
%T An Enantioselective Entry to
cis-Perhydroisoquinolines
%U https://acs.figshare.com/articles/journal_contribution/An_Enantioselective_Entry_to_i_cis_i_Perhydroisoquinolines/3272440
%R 10.1021/ol051242c.s001
%2 https://acs.figshare.com/ndownloader/files/5110165
%K enantioselective route
%K ci
%K Enantioselective Entry
%K cyclocondensation reaction
%K stereoselective conjugate addition
%K quaternary center
%K racemic oxoester
%K bicyclic lactam
%K carbocyclic ring
%X An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester,
a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis
as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary
center at the C4-position.
%I ACS Publications