%0 Journal Article %A Amat, Mercedes %A Pérez, Maria %A Minaglia, Annamaria T. %A Casamitjana, Núria %A Bosch, Joan %D 2005 %T An Enantioselective Entry to cis-Perhydroisoquinolines %U https://acs.figshare.com/articles/journal_contribution/An_Enantioselective_Entry_to_i_cis_i_Perhydroisoquinolines/3272440 %R 10.1021/ol051242c.s001 %2 https://acs.figshare.com/ndownloader/files/5110165 %K enantioselective route %K ci %K Enantioselective Entry %K cyclocondensation reaction %K stereoselective conjugate addition %K quaternary center %K racemic oxoester %K bicyclic lactam %K carbocyclic ring %X An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position. %I ACS Publications