Williams, Russell B. Norris, Andrew Slebodnick, Carla Merola, Joseph Miller, James S. Andriantsiferana, Rabodo Rasamison, Vincent E. G. I. Kingston, David Cytotoxic Sesquiterpene Lactones from <i>Vernonia pachyclada</i> from the Madagascar Rainforest Bioassay-guided fractionation of the cytotoxic leaf extract of <i>Vernonia </i><i>pachyclada</i> Baker led to the isolation of three new sesquiterpene lactones, designated glaucolides K−M (<b>1</b>−<b>3</b>). The structures of the new compounds were determined using 1D and 2D NMR spectroscopy, and the structure and stereochemistry of <b>1</b> were confirmed by single-crystal X-ray diffraction. Compound <b>3</b> showed moderate activity in the A2780 human ovarian cancer cell line, with an IC<sub>50</sub> of 3.3 μM. 3.3 μ M;Madagascar;compound;Vernonia pachyclada Baker;Vernonia pachyclada;sesquiterpene lactones;fractionation;cancer cell line;stereochemistry;cytotoxic leaf;glaucolide;Rainforest;1 D;IC 50;isolation;Cytotoxic Sesquiterpene Lactones;diffraction;Compound 3;2 D NMR spectroscopy 2005-09-23
    https://acs.figshare.com/articles/journal_contribution/Cytotoxic_Sesquiterpene_Lactones_from_i_Vernonia_pachyclada_i_from_the_Madagascar_Rainforest/3266689
10.1021/np050202e.s001