%0 Journal Article
%A Wang, Ying
%A Wang, Su-Juan
%A Mo, Shun-Yan
%A Li, Shuai
%A Yang, Yong-Chun
%A Shi, Jian-Gong
%D 2005
%T Phelligridimer A, a Highly Oxygenated
and Unsaturated 26-Membered
Macrocyclic Metabolite with Antioxidant
Activity from the Fungus Phellinus
igniarius
%U https://acs.figshare.com/articles/journal_contribution/Phelligridimer_A_a_Highly_Oxygenated_and_Unsaturated_26_Membered_Macrocyclic_Metabolite_with_Antioxidant_Activity_from_the_Fungus_i_Phellinus_igniarius_i_/3263572
%R 10.1021/ol0520875.s001
%2 https://acs.figshare.com/ndownloader/files/5101291
%K cancer cell lines
%K IC 50
%K Fungus Phellinus igniarius
%K enzymes PTP 1B
%K 50 μ M
%K 10 μ M
%K fungus Phellinus igniarius
%K metabolite
%K Phelligridimer
%K 25 μ M
%K 10.2 μ M
%X A highly oxygenated and unsaturated 26-membered macrocyclic metabolite, phelligridimer A (1), has been isolated from the Chinese medicinal
fungus Phellinus igniarius. Its structure was elucidated by spectroscopic methods. A possible biogenesis of 1 mediated by the fungal metabolite
hispidin was postulated. Phelligridimer A showed antioxidant activity (IC50 of 10.2 μM) but was inactive to several human cancer cell lines
(IC50 > 50 μM) and enzymes PTP1B (IC50 > 25 μM) and thrombin (IC50 > 10 μM).
%I ACS Publications