%0 Journal Article %A Wang, Ying %A Wang, Su-Juan %A Mo, Shun-Yan %A Li, Shuai %A Yang, Yong-Chun %A Shi, Jian-Gong %D 2005 %T Phelligridimer A, a Highly Oxygenated and Unsaturated 26-Membered Macrocyclic Metabolite with Antioxidant Activity from the Fungus Phellinus igniarius %U https://acs.figshare.com/articles/journal_contribution/Phelligridimer_A_a_Highly_Oxygenated_and_Unsaturated_26_Membered_Macrocyclic_Metabolite_with_Antioxidant_Activity_from_the_Fungus_i_Phellinus_igniarius_i_/3263572 %R 10.1021/ol0520875.s001 %2 https://acs.figshare.com/ndownloader/files/5101291 %K cancer cell lines %K IC 50 %K Fungus Phellinus igniarius %K enzymes PTP 1B %K 50 μ M %K 10 μ M %K fungus Phellinus igniarius %K metabolite %K Phelligridimer %K 25 μ M %K 10.2 μ M %X A highly oxygenated and unsaturated 26-membered macrocyclic metabolite, phelligridimer A (1), has been isolated from the Chinese medicinal fungus Phellinus igniarius. Its structure was elucidated by spectroscopic methods. A possible biogenesis of 1 mediated by the fungal metabolite hispidin was postulated. Phelligridimer A showed antioxidant activity (IC50 of 10.2 μM) but was inactive to several human cancer cell lines (IC50 > 50 μM) and enzymes PTP1B (IC50 > 25 μM) and thrombin (IC50 > 10 μM). %I ACS Publications