%0 Journal Article
%A Fairhurst, Robin A.
%A Janus, Diana
%A Lawrence, Annabel
%D 2005
%T Synthesis of the Marine Sponge Derived
β2-Adrenoceptor Agonist S1319
%U https://acs.figshare.com/articles/journal_contribution/Synthesis_of_the_Marine_Sponge_Derived_sub_2_sub_Adrenoceptor_Agonist_S1319/3263398
%R 10.1021/ol0518840.s001
%2 https://acs.figshare.com/ndownloader/files/5101117
%K adrenoceptor agonist S 1319
%K Marine Sponge Derived β 2
%K β 2
%K Adrenoceptor Agonist S 1319
%K cyclization precursor
%K marine sponge
%K butyl ether residue
%X The marine sponge derived β2-adrenoceptor agonist S1319 has been synthesized following a six-step linear sequence. Central to the approach
employed is the formation of a 7-lithiated-2,4-dialkoxybenzothiazole intermediate obtained via a directed-lithiation/benzyne-mediated cyclization
reaction. The incorporation of a tert-butyl ether residue into the cyclization precursor for the pivotal ring-closing step has been shown to
significantly increase the efficiency of the reaction by the suppression of a competing directed ortho-lithiation reaction.
%I ACS Publications